He was diagnosed with stage IV pancreatic cancer in January 2025 and he is still alive? Does that mean the vaccine worked? I thought that was a 3-6 month prognosis kind of deal.
But is there any demonstrated efficacy of this approach? You could just be throwing your money down the drain. What is this type of therapy referred to as in journals and what is its typical 5-year survival?
This is probably best framed as a Hail Mary experiment, albeit one with a sound theoretical basis, but not necessarily something that has been proven to move the needle.
There's millionaires and there's billionaires'. There's "is this even possible" in the first place. Rich people get to fund treatments for themselves but I can't wait till it's $30 and available at the store down the street.
This technology is in clinical trials, but people who need it now don't have years to wait for it. There's a lot of work to be done in engineering a legal landscape that allows people to access experimental treatments at costs as low as we can manage, without exposing manufacturers to damaging liability. I recommend this article about Jake Stillman's experience participating in clinical trials for terminal cancer (https://bessstillman.substack.com/p/please-be-dying-but-not-...) and this article by Ruxandra Teslo about bureaucratic bottlenecks in medical research (https://www.persuasion.community/p/medical-research-is-hopel...).
DNA in cancer cells is often scrambled beyond recognition, not just "damaged." And even magically replacing it with normal DNA may not solve your problem.
Complete story here: https://rnafoundry.com/yash/
He was diagnosed with stage IV pancreatic cancer in January 2025 and he is still alive? Does that mean the vaccine worked? I thought that was a 3-6 month prognosis kind of deal.
I do hope it works out.
Ok so digging into this: "We expect most projects to cost around $300,000 (USD) and take 8-10 weeks".
That's not quite democratized, but a first-world rush could well happen. I wonder how much costs can be brought down by automation.
But is there any demonstrated efficacy of this approach? You could just be throwing your money down the drain. What is this type of therapy referred to as in journals and what is its typical 5-year survival?
This is probably best framed as a Hail Mary experiment, albeit one with a sound theoretical basis, but not necessarily something that has been proven to move the needle.
There's millionaires and there's billionaires'. There's "is this even possible" in the first place. Rich people get to fund treatments for themselves but I can't wait till it's $30 and available at the store down the street.
I don't see anything expensive to do at scale in that GitHub repo
i don't understand, have they administered their vaccine to him already?
The last treatment update was from over a year ago, what has happened since then?
The whole thing seems a little disconnected.
not yet, they're working on vaccine for him.
Super cool, I’m more curious how this is manufactured. Would love to learn more about that
This better be the future! I love it.
An open development of a custom cancer vaccine? I had no idea this was a thing.
I am glad, someone is trying. Hope it works out! Someone did similar in the past: https://www.the-scientist.com/chatgpt-and-alphafold-help-des...
I wrote an article about Rosie here, back when this first came out: https://hedonicescalator.substack.com/p/did-paul-conyngham-r...
This technology is in clinical trials, but people who need it now don't have years to wait for it. There's a lot of work to be done in engineering a legal landscape that allows people to access experimental treatments at costs as low as we can manage, without exposing manufacturers to damaging liability. I recommend this article about Jake Stillman's experience participating in clinical trials for terminal cancer (https://bessstillman.substack.com/p/please-be-dying-but-not-...) and this article by Ruxandra Teslo about bureaucratic bottlenecks in medical research (https://www.persuasion.community/p/medical-research-is-hopel...).
I'm much rather see them repair damaged DNA in cancer cells to cure it.
DNA in cancer cells is often scrambled beyond recognition, not just "damaged." And even magically replacing it with normal DNA may not solve your problem.
"Scrambled beyond recognition" is a subjective term. If the DNA was hopelessly scrambled the cell wouldn't be able to survive.